MRNA vaccines for infectious diseases: principles, delivery and clinical translation.
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ABSTRACT:
SUBMITTER: Chaudhary N
PROVIDER: S-EPMC8386155 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
mRNA vaccines for infectious diseases: principles, delivery and clinical translation.
Chaudhary Namit N Weissman Drew D Whitehead Kathryn A KA
Nature reviews. Drug discovery 20210825 11
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront of those efforts. Although it is now clear that mRNA vaccines can rapidly and safely protect patients from infectious disease, additional research is required to optimize mRNA design, intracellular delivery and applications beyond SARS-CoV-2 prop ...[more]
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