Does Day-to-Day Variability in Stool Consistency Link to the Fecal Microbiota Composition?

ABSTRACT:

Introduction

Stool consistency has been associated with fecal microbial composition. Stool consistency often varies over time, in subjects with and without gastrointestinal disorders, raising the question whether variability in the microbial composition should be considered in microbiota studies. We evaluated within-subject day-to-day variability in stool consistency and the association with the fecal microbiota in irritable bowel syndrome (IBS) and healthy subjects, over seven days.

Methods

Twelve IBS patients and 12 healthy subjects collected fecal samples during seven consecutive days. Stool consistency was determined by the patient-reported Bristol Stool Scale (BSS) and fecal dry weight percentage. 16S rRNA V4 gene sequencing was performed and microbial richness (alpha d

SUBMITTER: Vork L 

PROVIDER: S-EPMC8386168 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature