Effects of Des-acyl Ghrelin on Insulin Sensitivity and Macrophage Polarization in Adipose Tissue.

ABSTRACT:

Background and objectives

Obesity is the accumulation of adipose tissue caused by excess energy in the body, accompanied by long-term chronic low-grade inflammation of adipose tissue. More than 50% of interstitial cells in adipose tissue are macrophages, which produce cytokines closely related to insulin resistance. Macrophage biology is driven by two polarization phenotypes, M1 (proinflammatory) and M2 (anti-inflammatory). This study aimed to investigate the effect of gastric hormone des-acyl ghrelin (DAG) on the polarization phenotype of macrophages and elucidate the role of macrophages in adipose tissue inflammation and insulin sensitivity and its molecular mechanism.

Methods

Mice were subcutaneously administrated with DAG in osmotic minipumps. The mice were fed a normal

SUBMITTER: Yuan F 

PROVIDER: S-EPMC8386331 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature