Preclinical Experiments for Hypospadias Surgery: Systematic Review and Quality Assessment.

ABSTRACT: Background: There is a steadily growing number of different reconstructive surgical procedures for hypospadias that were tested on animal models prior to their human application. However, the clinical translatability and reproducibility of the results encountered in preclinical urethral reconstruction experiments is considered poor, with significant factors contributing to the poor design and reporting of animal experiments. Our objective was to evaluate the quality of the design and reporting in published articles of urethral reconstructive preclinical studies. Methods: Both PubMed and EMBASE databases were searched for animal urethral repair experiments between January 2014 and September 2019. Internal quality (bias) was evaluated through several signaling questions arising

SUBMITTER: Abbas TO 

PROVIDER: S-EPMC8386350 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature