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FAK inhibitors as promising anticancer targets: present and future directions.


ABSTRACT: FAK, a nonreceptor tyrosine kinase, has been recognized as a novel target class for the development of targeted anticancer agents. Overexpression of FAK is a common occurrence in several solid tumors, in which the kinase has been implicated in promoting metastases. Consequently, designing and developing potent FAK inhibitors is becoming an attractive goal, and FAK inhibitors are being recognized as a promising tool in our armamentarium for treating diverse cancers. This review comprehensively summarizes the different classes of synthetically derived compounds that have been reported as potent FAK inhibitors in the last three decades. Finally, the future of FAK-targeting smart drugs that are designed to slow down the emergence of drug resistance is discussed.

SUBMITTER: Mustafa M 

PROVIDER: S-EPMC8386514 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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FAK inhibitors as promising anticancer targets: present and future directions.

Mustafa Muhamad M   Abd El-Hafeez Amer Ali AA   Abdelhafeez Dalia A DA   Abdelhamid Dalia D   Mostafa Yaser A YA   Ghosh Pradipta P   Hayallah Alaa M AM   A Abuo-Rahma Gamal El-Din GE  

Future medicinal chemistry 20210803 18


FAK, a nonreceptor tyrosine kinase, has been recognized as a novel target class for the development of targeted anticancer agents. Overexpression of FAK is a common occurrence in several solid tumors, in which the kinase has been implicated in promoting metastases. Consequently, designing and developing potent FAK inhibitors is becoming an attractive goal, and FAK inhibitors are being recognized as a promising tool in our armamentarium for treating diverse cancers. This review comprehensively su  ...[more]

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