A combined hypoxia and immune gene signature for predicting survival and risk stratification in triple-negative breast cancer.

ABSTRACT:

Background

Increasing evidence showed that the clinical significance of the interaction between hypoxia and immune status in tumor microenvironment. However, reliable biomarkers based on the hypoxia and immune status in triple-negative breast cancer (TNBC) have not been well established. This study aimed to explore a gene signature based on the hypoxia and immune status for predicting prognosis, risk stratification, and individual treatment in TNBC.

Methods

Hypoxia-related genes (HRGs) and Immune-related genes (IRGs) were identified using the weighted gene co-expression network analysis (WGCNA) method and the single-sample gene set enrichment analysis (ssGSEA Z-score) with the transcriptomic profiles from Molecular Taxonomy of Breast Cancer International Consortium (METABRIC

SUBMITTER: Yang X 

PROVIDER: S-EPMC8386525 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature