Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages.

ABSTRACT: Age-associated low-grade sterile inflammation, commonly referred to as inflammaging, is a recognized hallmark of aging, which contributes to many age-related diseases. While tissue-resident macrophages are innate immune cells that secrete many types of inflammatory cytokines in response to various stimuli, it is not clear whether they have a role in driving inflammaging. Here we characterized the transcriptional changes associated with physiological aging in mouse resident macrophage populations across different tissues and sexes. Although the age-related transcriptomic signatures of resident macrophages were strikingly tissue-specific, the differentially expressed genes were collectively enriched for those with important innate immune functions such as antigen presentation, cytokine produ

SUBMITTER: Babagana M 

PROVIDER: S-EPMC8386529 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature