Immune cell infiltration-associated signature in colon cancer and its prognostic implications.

ABSTRACT: Tumor immune cell infiltration (ICI) has been reported in various studies to be correlated with tumor diagnosis, clinical treatment sensitivity and prognosis. It is an important direction to study the characteristics of immune cell infiltration and develop new prognostic markers to improve the treatment of colon cancer. In this paper, we systematically analyzed the ICI characteristics and obtained three ICI clusters. Then, the ICI scores were constructed and its prognostic implications were discussed. From the results, the ICI score patterns were linked to a great survival difference (p<0.001). A high ICI score was characterized by a higher fraction of plasma cells, CD8⁺ T cells, memory resting CD4⁺ T cells, monocytes, eosinophils and dendritic cells, which had better

SUBMITTER: Deng D 

PROVIDER: S-EPMC8386549 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature