Features of age-related response to sleep deprivation: in vivo experimental studies.

ABSTRACT: Insomnia is currently considered one of the potential triggers of accelerated aging. The frequency of registered sleep-wake cycle complaints increases with age and correlates with the quality of life of elderly people. Nevertheless, whether insomnia is actually an age-associated process or whether it acts as an independent stress-factor that activates pathological processes, remains controversial. In this study, we analyzed the effects of long-term sleep deprivation modeling on the locomotor and orienting-exploratory activity, spatial learning abilities and working memory of C57BL/6 female mice of different ages. We also evaluated the modeled stress influence on morphological changes in brain tissue, the functional activity of the mitochondrial apparatus of nerve cells, and the level of DN

SUBMITTER: Novozhilova M 

PROVIDER: S-EPMC8386558 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature