A general, versatile and divergent synthesis of selectively deuterated amines.

ABSTRACT: Deuterated organic molecules are of utmost importance in many areas of science and have been recently intensively investigated in medicinal chemistry due to their enhanced metabolic stability. The development of efficient and broadly applicable methods for the selective incorporation of deuterium atoms into organic molecules from readily available starting materials and reagents is therefore of extreme importance. Such methods however often lack generality and selectivity, notably in the nitrogen series. With nitrogen-containing molecules being indeed ubiquitous in medicinal chemistry, there is a strong need for efficient methods enabling the selective synthesis of deuterated amines. In this perspective, we report herein a general, versatile, divergent and metal-free synthesis of amines se

SUBMITTER: Lecomte M 

PROVIDER: S-EPMC8386668 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature