Biomarkers for early detection of pancreatic cancer - miRNAs as a potential diagnostic and therapeutic tool?
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ABSTRACT:
SUBMITTER: Tarasiuk A
PROVIDER: S-EPMC8386725 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Biomarkers for early detection of pancreatic cancer - miRNAs as a potential diagnostic and therapeutic tool?
Tarasiuk Aleksandra A Mackiewicz Tomasz T Małecka-Panas Ewa E Fichna Jakub J
Cancer biology & therapy 20210601 5-6
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, with poor prognosis resulting mostly from late diagnosis. Surgery remains the most effective treatment and early detection significantly increases the overall survival. Biomarkers used for diagnosis and to monitor the response to treatment, such as carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA), are not adequate as early detection markers of PDAC, partly due to low sensitivity/specificity. Theref ...[more]
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