Predictors of development of cardiac and digestive disorders among patients with indeterminate chronic Chagas Disease.

ABSTRACT: American trypanosomiasis (Chagas disease, CD) affects circa 7 million persons worldwide. While of those persons present the asymptomatic, indeterminate chronic form (ICF), many will eventually progress to cardiac or digestive disorders. We studied a nonconcurrent (retrospective) cohort of patients attending an outpatient CD clinic in Southeastern Brazil, who were admitted while presenting the ICF in the period from 1998 through 2018 and followed until 2019. The outcomes of interest were the progression to cardiac or digestive CD forms. We were also interested in analyzing the impact of Benznidazole therapy on the progression of the disease. Extensive review of medical charts and laboratory files was conducted, collecting data up to year 2019. Demographics (upon inclusion), body mass index,

SUBMITTER: Nunes da Costa EAP 

PROVIDER: S-EPMC8386853 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature