Clinical correlates of circulating cell-free DNA tumor fraction.

ABSTRACT:

Background

Oncology applications of cell-free DNA analysis are often limited by the amount of circulating tumor DNA and the fraction of cell-free DNA derived from tumor cells in a blood sample. This circulating tumor fraction varies widely between individuals and cancer types. Clinical factors that influence tumor fraction have not been completely elucidated.

Methods and findings

Circulating tumor fraction was determined for breast, lung, and colorectal cancer participant samples in the first substudy of the Circulating Cell-free Genome Atlas study (CCGA; NCT02889978; multi-cancer early detection test development) and was related to tumor and patient characteristics. Linear models were created to determine the influence of tumor size combined with mitotic or metabolic activi

SUBMITTER: Bredno J 

PROVIDER: S-EPMC8386888 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature