Epigenetic regulation during human cortical development: Seq-ing answers from the brain to the organoid.

ABSTRACT: Epigenetic regulation plays an important role in controlling gene expression during complex processes, such as development of the human brain. Mutations in genes encoding chromatin modifying proteins and in the non-protein coding sequences of the genome can potentially alter transcription factor binding or chromatin accessibility. Such mutations can frequently cause neurodevelopmental disorders, therefore understanding how epigenetic regulation shapes brain development is of particular interest. While epigenetic regulation of neural development has been extensively studied in murine models, significant species-specific differences in both the genome sequence and in brain development necessitate human models. However, access to human fetal material is limited and these tissues cannot be gro

SUBMITTER: Lewis EMA 

PROVIDER: S-EPMC8387070 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature