Apolipoprotein E4 Moderates the Association Between Vascular Risk Factors and Brain Pathology.

ABSTRACT:

Background

The strongest genetic risk factor for late-onset Alzheimer disease (AD), Apolipoprotein E4 (APOE4), increases cardiovascular disease risk and may also act synergistically with vascular risk factors to contribute to AD pathogenesis. Here, we assess the interaction between APOE4 and vascular risk on cerebrovascular dysfunction and brain pathology.

Methods

This is an observational study of cognitively normal older adults, which included positron emission tomography imaging and vascular risk factors. We measured beat-to-beat blood pressure and middle cerebral artery velocity at rest and during moderate-intensity exercise. Cerebrovascular measures included cerebrovascular conductance index and the cerebrovascular response to exercise.

Results

There was a signifi

SUBMITTER: Kaufman CS 

PROVIDER: S-EPMC8387316 | biostudies-literature | 2021 Jul-Sep 01

REPOSITORIES: biostudies-literature