Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis.

ABSTRACT:

Background and purpose

The extra medical use of, and addiction to, prescription opioid analgesics is a growing health problem. To characterize how prescription opioid abuse develops, this study investigated the affective consequences of escalating prescription opioid use using intracranial self-stimulation (ICSS) reward and oxycodone intravenous self-administration (IVSA) models.

Experimental approach

Male Wistar rats were given access to oxycodone IVSA (0.15 mg·kg^-1 per infusion, i.v.) in short-access (ShA; 1 h) or long-access (LgA; 12 h) sessions for five sessions per week followed by intermittent 60-h discontinuations from drug access, a novel explicit test of the negative reinforcement hypothesis. Separate groups were first trained in the ICSS procedure and th

SUBMITTER: Nguyen JD 

PROVIDER: S-EPMC8387405 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature