Protein Immunization Induces Memory CD4⁺ T Cells That Lack Th Lineage Commitment.

ABSTRACT: Acute viral infection generates lineage-committed Th1 and T follicular helper (Tfh) memory cells that recall their lineage-specific functions following secondary challenge with virus. However, the lineage commitment of effector and memory Th cells in vivo following protein vaccination is poorly understood. In this study, we analyzed effector and memory CD4⁺ T cell differentiation in mice (Mus musculus) following adjuvanted glycoprotein immunization compared with acute lymphocytic choriomeningitis virus infection. Glycoprotein immunization induced CXCR5^- non-Tfh effector and memory CD4⁺ T cells that surprisingly had not undergone polarization toward any particular Th cell lineage but had undergone memory differentiation. However, upon challenge with v

SUBMITTER: Sircy LM 

PROVIDER: S-EPMC8387422 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature