Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer.

ABSTRACT:

Background

Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC). The primary aim of the study is to assess the relationship between the plasma lipidome and clinical outcomes in localised and metastatic PC. The secondary aim is to validate a prognostic circulating 3-lipid signature specific to metastatic castration-resistant PC (mCRPC).

Patients and methods

Comprehensive lipidomic analysis was performed on pre-treatment plasma samples from men with localised PC (N = 389), metastatic hormone-sensitive PC (mHSPC)(N = 44), or mCRPC (validation cohort, N = 137). Clinical outcomes from our previously published mCRPC cohort (N = 159) that was used to derive the prognostic circulating 3-lipid signature, were updated.

SUBMITTER: Lin HM 

PROVIDER: S-EPMC8387438 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature