Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.

ABSTRACT: T cells are essential mediators of immune responses against infectious diseases and provide long-lived protection from reinfection. The differentiation of naive to effector T cells and the subsequent differentiation and persistence of memory T cell populations in response to infection is a highly regulated process. E protein transcription factors and their inhibitors, Id proteins, are important regulators of both CD4⁺ and CD8⁺ T cell responses; however, their regulation at the protein level has not been explored. Recently, the deubiquitinase USP1 was shown to stabilize Id2 and modulate cellular differentiation in osteosarcomas. In this study, we investigated a role for Usp1 in posttranslational control of Id2 and Id3 in murine T cells. We show that Usp1 was upregulate

SUBMITTER: Omilusik KD 

PROVIDER: S-EPMC8387442 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature