Genome-wide association study reveals an association between the HLA-DPB1^∗02:01:02 allele and wheat-dependent exercise-induced anaphylaxis.

ABSTRACT: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a life-threatening food allergy triggered by wheat in combination with the second factor such as exercise. The identification of potential genetic risk factors for this allergy might help high-risk individuals before consuming wheat-containing food. We aimed to identify genetic variants associated with WDEIA. A genome-wide association study was conducted in a discovery set of 77 individuals with WDEIA and 924 control subjects via three genetic models. The associations were confirmed in a replication set of 91 affected individuals and 435 control individuals. Summary statistics from the combined set were analyzed by meta-analysis with a random-effect model. In the discovery set, a locus on chromosome 6, rs9277630, was associated with W

SUBMITTER: Fukunaga K 

PROVIDER: S-EPMC8387458 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature