Supraphysiological effects of pancreatic polypeptide on gastric motor function and nutrient tolerance in humans.

ABSTRACT: Pancreatic polypeptide (PP) is known to affect food intake. In this exploratory study, we set out to investigate its supraphysiological effect on food tolerance, gastric accommodation, and emptying. In 12 healthy volunteers, 0, 3, or 10 pmol*kg^-1 *min^-1 PP was administered intravenously (PP0, PP3 or PP10). Thirty minutes thereafter, nutrient drink infusion (60 ml*min^-1 ) through a nasogastric feeding tube was started until maximum satiation. Gastric accommodation was assessed by measuring the intragastric pressure (IGP; nasogastric manometry). In a separate test, the effect of PP0 or PP10 on gastric emptying was tested in 10 healthy volunteers and assessed using the ¹³ C breath test. Results are presented as mean ± SEM, and p < 0.05 was considere

SUBMITTER: Verbeure W 

PROVIDER: S-EPMC8387790 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature