Exosomes: Biomarkers and Therapeutic Targets of Diabetic Vascular Complications.

ABSTRACT: Diabetic vascular complications (DVC) including macrovascular and microvascular lesions, have a significant impact on public health, and lead to increased patient mortality. Disordered intercellular cascades play a vital role in diabetic systemic vasculopathy. Exosomes participate in the abnormal signal transduction of local vascular cells and mediate the transmission of metabolic disorder signal molecules in distant organs and cells through the blood circulation. They can store different signaling molecules in the membrane structure and release them into the blood, urine, and tears. In recent years, the carrier value and therapeutic effect of exosomes derived from stem cells have garnered attention. Exosomes are not only a promising biomarker but also a potential target and tool for the t

SUBMITTER: Chen A 

PROVIDER: S-EPMC8387814 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature