Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis.

ABSTRACT:

Background

The protein 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a key stimulator of glycolytic flux. Systemic, partial PFKFB3 inhibition previously decreased total plaque burden and increased plaque stability. However, it is unclear which cell type conferred these positive effects. Myeloid cells play an important role in atherogenesis, and mainly rely on glycolysis for energy supply. Thus, we studied whether myeloid inhibition of PFKFB3-mediated glycolysis in Ldlr^-/-LysMCre^+/-Pfkfb3 ^fl/fl (Pfkfb3 ^fl/fl ) mice confers beneficial effects on plaque stability and alleviates cardiovascular disease burden compared to Ldlr^-/-LysMCre^+/-Pfkfb3 ^wt/wt

SUBMITTER: Tillie RJHA 

PROVIDER: S-EPMC8387953 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature