Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz-Torres V
PROVIDER: S-EPMC8388012 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Ruiz-Torres Verónica V Forsythe Nicholas N Pérez-Sánchez Almudena A Van Schaeybroeck Sandra S Barrajón-Catalán Enrique E Micol Vicente V
Frontiers in pharmacology 20210408
The present study shows the putative antiproliferative mechanism of action of the previously analytically characterized nudibranch extract (<i>Dolabella auricularia,</i> NB) and its different effects in colon cancer cells vs. nontumor colon cells. NB extract increased the accumulation of reactive oxygen species (ROS) and increased endoplasmic reticulum (ER) stress via stimulation of the unfolded protein response. Stress scavengers, N-acetylcysteine (NAC) and 4-phenylbutyric acid (4-PBA), decreas ...[more]