CuBlock: a cross-platform normalization method for gene-expression microarrays.

ABSTRACT:

Motivation

Cross-(multi)platform normalization of gene-expression microarray data remains an unresolved issue. Despite the existence of several algorithms, they are either constrained by the need to normalize all samples of all platforms together, compromising scalability and reuse, by adherence to the platforms of a specific provider, or simply by poor performance. In addition, many of the methods presented in the literature have not been specifically tested against multi-platform data and/or other methods applicable in this context. Thus, we set out to develop a normalization algorithm appropriate for gene-expression studies based on multiple, potentially large microarray sets collected along multiple platforms and at different times, applicable in systematic studies aimed at ext

SUBMITTER: Junet V 

PROVIDER: S-EPMC8388031 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature