Effects of processed meat and drinking water nitrate on oral and fecal microbial populations in a controlled feeding study.

ABSTRACT:

Background

One mechanism that can explain the link between processed meat consumption and colorectal cancer (CRC) is the production of carcinogenic N-nitroso compounds (NOCs) in the gastrointestinal tract. Oral and gut microbes metabolize ingested proteins (a source of secondary and tertiary amines and amides) and can reduce nitrate to nitrite, generating potentially carcinogenic NOCs.

Objective

We evaluated whether nitrate/nitrite in processed meat or water influences the fecal or salivary microbiota.

Design

In this dietary intervention study, 63 volunteers consumed diets high in conventional processed meats for two weeks, switched to diets high in poultry for two weeks, and then consumed phytochemical-enriched conventional processed or low-nitrite processed meat die

SUBMITTER: Sinha R 

PROVIDER: S-EPMC8388086 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature