Low level of stromal lectin-like oxidized LDL receptor 1 and CD8⁺ cytotoxic T-lymphocytes indicate poor prognosis of colorectal cancer.

ABSTRACT:

Background

Lectin-like oxidized LDL receptor-1 (LOX-1) has been identified as a new marker for functional myeloid-derived suppressor cells (MDSCs) that exhibit an immunosuppressive phenotype in the tumor microenvironment (TME). However, the role of LOX-1⁺ cells in the TME of colorectal cancer (CRC) remains unknown.

Aim

This study aimed to determine the expression and significance of LOX-1 in the TME of clinical CRC specimens.

Methods and results

We performed immunohistochemical and genetic analyses of LOX-1, CD8, KRAS, and BRAF in 128 resected CRC specimens and determined the expression of IFN-γ and IL-10 using real-time reverse transcription-polymerase chain reaction. We analyzed the correlation between LOX-1, TME factors, gene alteration, clinicopathologi

SUBMITTER: Katayama C 

PROVIDER: S-EPMC8388181 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature