An Emerging Role of miRNAs in Neurodegenerative Diseases: Mechanisms and Perspectives on miR146a.

ABSTRACT: Significance: Advancements in and access to health care have led to unprecedented improvements in the quality of life and increased lifespan of human beings in the past century. However, aging is a significant risk factor for neurodegenerative diseases (NDs). Hence, improved life expectancy has led to an increased incidence of NDs. Despite intense research, effective treatments for NDs remain elusive. The future of neurotherapeutics development depends on effective disease modification strategies centered on carefully scrutinized targets. Recent Advances: As a promising new direction, recent evidence has demonstrated that epigenetic processes modify diverse biochemical pathways, including those related to NDs. Small non-coding RNAs, known as microRNAs (miRNAs),

SUBMITTER: Ammal Kaidery N 

PROVIDER: S-EPMC8388248 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature