Design of a Novel Multi-Epitope Vaccine Against Echinococcus granulosus in Immunoinformatics.

ABSTRACT: All the time, echinococcosis is a global zoonotic disease which seriously endangers public health all over the world. In order to speed up the development process of anti-Echinococcus granulosus vaccine, at the same time, it can also save economic cost. In this study, immunoinformatics tools and molecular docking methods were used to predict and screen the antigen epitopes of Echinococcus granulosus, to design a multi-epitope vaccine containing B- and T-cell epitopes. The multi-epitope vaccine could activate B lymphocytes to produce specific antibodies theoretically, which could protect the human body against Echinococcus granulosus infection. It also could activate T lymphocytes and clear the infected parasites in the body. In this study, four CD8⁺ T-cell e

SUBMITTER: Yu M 

PROVIDER: S-EPMC8388843 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature