Multidrug-Resistant Klebsiella pneumoniae Causing Severe Infections in the Neuro-ICU.

ABSTRACT: The purpose of this study was the identification of genetic lineages and antimicrobial resistance (AMR) and virulence genes in Klebsiella pneumoniae isolates associated with severe infections in the neuro-ICU. Susceptibility to antimicrobials was determined using the Vitek-2 instrument. AMR and virulence genes, sequence types (STs), and capsular types were identified by PCR. Whole-genome sequencing was conducted on the Illumina MiSeq platform. It was shown that K. pneumoniae isolates of ST14^K2, ST23^K57, ST39^K23, ST76^K23, ST86^K2, ST218^K57, ST219^KL125/114, ST268^K20, and ST2674^K47 caused severe systemic infections, including ST14^K2, ST39^K23, and ST268^K20<

SUBMITTER: Fursova NK 

PROVIDER: S-EPMC8389041 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature