HnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.

ABSTRACT: The hnRNP A/B family of proteins is canonically central to cellular RNA metabolism, but due to their highly conserved nature, the functional differences between hnRNP A1, A2/B1, A0, and A3 are often overlooked. In this review, we explore and identify the shared and disparate homeostatic and disease-related functions of the hnRNP A/B family proteins, highlighting areas where the proteins have not been clearly differentiated. Herein, we provide a comprehensive assembly of the literature on these proteins. We find that there are critical gaps in our grasp of A/B proteins' alternative splice isoforms, structures, regulation, and tissue and cell-type-specific functions, and propose that future mechanistic research integrating multiple A/B proteins will significantly improve our understanding of

SUBMITTER: Thibault PA 

PROVIDER: S-EPMC8389229 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature