<i>Mycobacterium tuberculosis</i> H₂S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility.

ABSTRACT: H₂S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H₂S has been shown to profoundly alter M. tuberculosis (Mtb) energy metabolism and growth. However, compelling evidence for endogenous production of H₂S and its role in Mtb physiology is lacking. We show that multidrug-resistant and drug-susceptible clinical Mtb strains produce H₂S, whereas H₂S production in non-pathogenic M. smegmatis is barely detectable. We identified Rv3684 (Cds1) as an H₂S-producing enzyme in Mtb and show that cds1 disruption reduces, but does not eliminate, H₂S production, suggesting the involvement of multiple genes in H₂S production. We identified endogenous

SUBMITTER: Kunota TTR 

PROVIDER: S-EPMC8389258 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature