Tumor-Induced Cardiac Dysfunction: A Potential Role of ROS.

ABSTRACT: Cancer and heart diseases are the two leading causes of mortality and morbidity worldwide. Many cancer patients undergo heart-related complications resulting in high incidences of mortality. It is generally hypothesized that cardiac dysfunction in cancer patients occurs due to cardiotoxicity induced by therapeutic agents, used to treat cancers and/or cancer-induced cachexia. However, it is not known if localized tumors or unregulated cell growth systemically affect heart function before treatment, and/or prior to the onset of cachexia, hence, making the heart vulnerable to structural or functional abnormalities in later stages of the disease. We incorporated complementary mouse and Drosophila models to establish if tumor induction indeed causes cardiac defects even before interventi

SUBMITTER: Karekar P 

PROVIDER: S-EPMC8389295 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature