A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.

ABSTRACT:

Objective

To develop an index assessing the risks of low energy fractures (LEF) in patients prescribed antiepileptic drugs (AED) by exploring five previously suggested risk factors; age, gender, AED-type, epilepsy diagnosis and BMI.

Methods

In a population-based retrospective open cohort study we used real world data from the Electronic Health Register (EHR) in Region Kalmar County, Sweden. 23 209 patients prescribed AEDs at any time from January 2008 to November 2018 and 23 281 matching controls were followed from first registration in the EHR until the first documented LEF, disenrollment (or death) or until the end of the study period, whichever came first. Risks of LEF measured as hazard rate ratios in relation to the suggested risk factors and in comparison to matched co

SUBMITTER: Nordqvist O 

PROVIDER: S-EPMC8389492 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature