Microglia: The Real Foe in HIV-1-Associated Neurocognitive Disorders?

ABSTRACT: The current use of combined antiretroviral therapy (cART) is leading to a significant decrease in deaths and comorbidities associated with human immunodeficiency virus type 1 (HIV-1) infection. Nonetheless, none of these therapies can extinguish the virus from the long-lived cellular reservoir, including microglia, thereby representing an important obstacle to curing HIV. Microglia are the foremost cells infected by HIV-1 in the central nervous system (CNS) and are believed to be involved in the development of HIV-1-associated neurocognitive disorder (HAND). At present, the pathological mechanisms contributing to HAND remain unclear, but evidence suggests that removing these infected cells from the brain, as well as obtaining a better understanding of the specific molecular mechanisms of H

SUBMITTER: Borrajo Lopez A 

PROVIDER: S-EPMC8389599 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature