Targeting Small GTPases and Their Prenylation in Diabetes Mellitus.

ABSTRACT: A fundamental role of pancreatic β-cells to maintain proper blood glucose level is controlled by the Ras superfamily of small GTPases that undergo post-translational modifications, including prenylation. This covalent attachment with either a farnesyl or a geranylgeranyl group controls their localization, activity, and protein-protein interactions. Small GTPases are critical in maintaining glucose homeostasis acting in the pancreas and metabolically active tissues such as skeletal muscles, liver, or adipocytes. Hyperglycemia-induced upregulation of small GTPases suggests that inhibition of these pathways deserves to be considered as a potential therapeutic approach in treating T2D. This Perspective presents how inhibition of various points in the mevalonate pathway might affect protein pre

SUBMITTER: Gendaszewska-Darmach E 

PROVIDER: S-EPMC8389838 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature