B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma.

ABSTRACT:

Aim

Neuroblastoma is the most common extracranial solid tumor in children. Recent advances in immunotherapy Approaches, including in neuroblastoma, have shown the important role of the immune system in mounting an effective anti-tumor response. In this study, we aimed to provide a comprehensive investigation of immune cell infiltration in neuroblastoma utilizing a large number of gene expression datasets.

Methods

We inferred immune cell infiltration using an established immune inference method and evaluated the association between immune cell abundance and patient prognosis as well as common chromosomal abnormalities found in neuroblastoma. In addition, we evaluated co-infiltration patterns among distinct immune cell types.

Results

The infiltration of naïve B cells, N

SUBMITTER: Schaafsma E 

PROVIDER: S-EPMC8389852 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature