Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort.

ABSTRACT:

Background

Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, as gatekeepers against invading infectious agents through rapid secretion of immune regulatory cytokines. HIV associated destruction of mucosal lymphoid tissue depletes ILCs, among other immune dysfunctions. Studies have described limited restoration of ILCs during the first three years of combined antiretroviral therapy (cART). Little is known about restoration of ILCs during long-term cART, particularly in sub-Saharan Africa which hosts increasing numbers of adults with at least a decade of cART.

Results

We examined phenotypes and function of ILCs from peri

SUBMITTER: Nabatanzi R 

PROVIDER: S-EPMC8390268 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature