Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition associated with aging, insulin resistance, metabolic syndrome, genetic factors and more. Although genetic traits are among the most important risks factors for NAFLD, the understanding of their influence is still quite limited. The present study aimed at identifying novel single nucleotide polymorphisms (SNPs) that may confer a risk for NAFLD in the Han Chinese population.

Methods

Based on the "two-hit hypothesis", candidate SNPs, including Sirtuin3 rs28365927, were genotyped by MassARRAY in B-type ultrasonography-proven NAFLD patients (n = 292) and healthy controls (n = 387).

Results

In a model analysis of individuals matched based on gender and age that compared 223 NAFLD and 223 non-

SUBMITTER: Chen LJ 

PROVIDER: S-EPMC8390275 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature