Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.

ABSTRACT:

Background

Malaria still constitutes a major public health menace, especially in tropical and subtropical countries. Close to half a million people mainly children in Africa, die every year from the disease. With the rising resistance to frontline drugs (artemisinin-based combinations), there is a need to accelerate the discovery and development of newer anti-malarial drugs. A systematic review was conducted to identify the African medicinal plants with significant antiplasmodial and/or anti-malarial activity, toxicity, as wells as assessing the variation in their activity between study designs (in vitro and in vivo).

Methods

Key health-related databases including Google Scholar, PubMed, PubMed Central, and Science Direct were searched for relevant literature on the antiplas

SUBMITTER: Tajbakhsh E 

PROVIDER: S-EPMC8390284 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature