Evolution of antibody responses up to 13 months after SARS-CoV-2 infection and risk of reinfection.

ABSTRACT:

Background

Assessment of the kinetics of SARS-CoV-2 antibodies is essential in predicting risk of reinfection and durability of vaccine protection.

Methods

This is a prospective, monocentric, longitudinal, cohort clinical study. Healthcare workers (HCW) from Strasbourg University Hospital were enrolled between April 6th and May 7th, 2020 and followed up to 422 days. Serial serum samples were tested for antibodies against the Receptor Binding Domain (RBD) of the spike protein and nucleocapsid protein (N) to characterize the kinetics of SARS-CoV-2 antibodies and the incidence of reinfection. Live-neutralization assays were performed for a subset of samples before and after vaccination to analyze sensitivity to SARS-CoV-2 variants.

Findings

A total of 4290 samples from 3

SUBMITTER: Gallais F 

PROVIDER: S-EPMC8390300 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature