Generation of avian-derived anti-B7-H4 antibodies exerts a blockade effect on the immunosuppressive response.

ABSTRACT: For highly conserved mammalian protein, chicken is a suitable immune host to generate antibodies. Monoclonal antibodies have been successfully targeted with immunity checkpoint proteins as a means of cancer treatment; this treatment enhances tumor-specific immunity responses through immunoregulation. Studies have identified the importance of B7-H4 in immunoregulation and its use as a potential target for cancer treatment. High levels of B7-H4 expression are found in tumor tissues and are associated with adverse clinical and pathological characteristics. Using the phage display technique, this study isolated specific single-chain antibody fragments (scFvs) against B7-H4 from chickens. Our experiment proved that B7-H4 clearly induced the inhibition of T-cell activation. Therefore, use of ant

SUBMITTER: Lin TY 

PROVIDER: S-EPMC8390317 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature