Causal contributors to tissue stiffness and clinical relevance in urology.

ABSTRACT: Mechanomedicine is an emerging field focused on characterizing mechanical changes in cells and tissues coupled with a specific disease. Understanding the mechanical cues that drive disease progression, and whether tissue stiffening can precede disease development, is crucial in order to define new mechanical biomarkers to improve and develop diagnostic and prognostic tools. Classically known stromal regulators, such as fibroblasts, and more recently acknowledged factors such as the microbiome and extracellular vesicles, play a crucial role in modifications to the stroma and extracellular matrix (ECM). These modifications ultimately lead to an alteration of the mechanical properties (stiffness) of the tissue, contributing to disease onset and progression. We describe here classic and emergi

SUBMITTER: Martinez-Vidal L 

PROVIDER: S-EPMC8390675 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature