Oligodendrocytic Na⁺-K⁺-Cl^- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain.

ABSTRACT: The juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na⁺-K⁺-Cl^- co-transporter 1 (NKCC1), highly expressed in the juvenile mouse brain, regulates the oligodendrocyte activity from juvenile to adulthood in mice, as shown by optogenetic manipulation of oligodendrocytes. The reduced neuronal activity in adults was restored by Nkcc1 overexpression in oligodendrocytes. Moreover, in adult mice overexpressing Nkcc1, long-term potentiation and learning were facilitated compared to age-matched controls. These findings demonstrate that NK

SUBMITTER: Yamazaki Y 

PROVIDER: S-EPMC8390751 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature