Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement.

ABSTRACT: Immune checkpoint blockade antibodies have promising clinical applications but suffer from disadvantages such as severe toxicities and moderate patient-response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower systemic toxicities or to augment therapeutic response, is not possible. Herein, we develop an implantable miniaturized device using electrode-embedded optical fibers with both local delivery and measurement capabilities over the course of a few weeks. The combination of local immune checkpoint blockade antibodies delivery via this device with photodynamic therapy elicits a sustained anti-tumor immunity in multiple tumor mo

SUBMITTER: Chin AL 

PROVIDER: S-EPMC8390758 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature