Identification of Genes Contributing to a Long Circadian Period in <i>Drosophila Melanogaster</i>.

ABSTRACT: The endogenous circadian period of animals and humans is typically very close to 24 h. Individuals with much longer circadian periods have been observed, however, and in the case of humans, these deviations have health implications. Previously, we observed a line of Drosophila with a very long average period of 31.3 h for locomotor activity behavior. Preliminary mapping indicated that the long period did not map to known canonical clock genes but instead mapped to multiple chromosomes. Using RNA-Seq, we surveyed the whole transcriptome of fly heads from this line across time and compared it with a wild-type control. A three-way generalized linear model revealed that approximately two-thirds of the genes were expressed differentially among the two genotypes, while only one quarter of

SUBMITTER: Kumar S 

PROVIDER: S-EPMC8390771 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature