Fast bilayer-micelle fusion mediated by hydrophobic dipeptides.

ABSTRACT: To understand the transition from inanimate matter to life, we studied a process that directly couples simple metabolism to evolution via natural selection, demonstrated experimentally by Adamala and Szostak. In this process, dipeptides synthesized inside precursors of cells promote absorption of fatty acid micelles to vesicles, inducing their preferential growth and division at the expense of other vesicles. The process is explained on the basis of coarse-grained molecular dynamics simulations, each extending for tens of microseconds, carried out to model fusion between a micelle and a membrane, both made of fatty acids in the absence and presence of hydrophobic dipeptides. In all systems with dipeptides, but not in their absence, fusion events were observed. They involve the formation of

SUBMITTER: Wei C 

PROVIDER: S-EPMC8390801 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature