Stochastic reaction-diffusion modeling of calcium dynamics in 3D dendritic spines of Purkinje cells.

ABSTRACT: Calcium (Ca²⁺) is a second messenger assumed to control changes in synaptic strength in the form of both long-term depression and long-term potentiation at Purkinje cell dendritic spine synapses via inositol trisphosphate (IP₃)-induced Ca²⁺ release. These Ca²⁺ transients happen in response to stimuli from parallel fibers (PFs) from granule cells and climbing fibers (CFs) from the inferior olivary nucleus. These events occur at low numbers of free Ca²⁺, requiring stochastic single-particle methods when modeling them. We use the stochastic particle simulation program MCell to simulate Ca²⁺ transients within a three-dimensional Purkinje cell dendritic spine. The model spine includes the endoplasmic reticulum, several Ca^2+<

SUBMITTER: Friedhoff VN 

PROVIDER: S-EPMC8390834 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature