Dataset Information

Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

ABSTRACT: SARS-CoV-2 variants emerged in late 2020, and at least three variants of concern (B.1.1.7, B.1.351, and P1) have been reported by WHO. These variants have several substitutions in the spike protein that affect receptor binding; they exhibit increased transmissibility and may be associated with reduced vaccine effectiveness. In the present work, we report the identification of a potential variant of interest, harboring the mutations T478K, P681H, and T732A in the spike protein, within the newly named lineage B.1.1.519, that rapidly outcompeted the preexisting variants in Mexico and has been the dominant virus in the country during the first trimester of 2021.

SUBMITTER: Rodriguez-Maldonado AP

PROVIDER: S-EPMC8390838 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

Rodríguez-Maldonado Abril Paulina AP Vázquez-Pérez Joel Armando JA Cedro-Tanda Alberto A Taboada Blanca B Boukadida Celia C Wong-Arámbula Claudia C Nuñez-García Tatiana Ernestina TE Cruz-Ortiz Natividad N Barrera-Badillo Gisela G Hernández-Rivas Lucía L López-Martínez Irma I Mendoza-Vargas Alfredo A Reyes-Grajeda Juan Pablo JP Alcaraz Nicolas N Peñaloza-Figueroa Fernando F Gonzalez-Barrera Dulibeth D Rangel-DeLeon Daniel D Herrera-Montalvo Luis Alonso LA Mejía-Nepomuceno Fidencio F Hernández-Terán Alejandra A Mújica-Sánchez Mario M Becerril-Vargas Eduardo E Martínez-Orozco José Arturo JA Pérez-Padilla Rogelio R Salas-Hernández Jorge J Sanchez-Flores Alejandro A Isa Pavel P Matías-Florentino Margarita M Ávila-Ríos Santiago S Muñoz-Medina José Esteban JE Grajales-Muñiz Concepción C Salas-Lais Angel Gustavo AG Santos Coy-Arechavaleta Andrea A Hidalgo-Miranda Alfredo A Arias Carlos F CF Ramírez-González José Ernesto JE

Archives of virology 20210827 11

SARS-CoV-2 variants emerged in late 2020, and at least three variants of concern (B.1.1.7, B.1.351, and P1) have been reported by WHO. These variants have several substitutions in the spike protein that affect receptor binding; they exhibit increased transmissibility and may be associated with reduced vaccine effectiveness. In the present work, we report the identification of a potential variant of interest, harboring the mutations T478K, P681H, and T732A in the spike protein, within the newly n ...[more]

PMID: 34448936

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Dataset Information

Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

Publications

Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

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