Local actin dynamics couple speed and persistence in a cellular Potts model of cell migration.

ABSTRACT: Cell migration is astoundingly diverse. Molecular signatures, cell-cell interactions, and environmental structures each play their part in shaping cell motion, yielding numerous morphologies and migration modes. Nevertheless, in recent years, a simple unifying law was found to describe cell migration across many different cell types and contexts: faster cells turn less frequently. This universal coupling between speed and persistence (UCSP) was explained by retrograde actin flow from front to back, but it remains unclear how this mechanism generalizes to cells with complex shapes and cells migrating in structured environments, which may not have a well-defined front-to-back orientation. Here, we present an in-depth characterization of an existing cellular Potts model, in which cells polari

SUBMITTER: Wortel IMN 

PROVIDER: S-EPMC8390880 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature